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GHS guidance

Guidance on the application of GHS criteria

 

Section 1: Examples on the application of GHS criteria
(click on the chapter to expand)

Acute toxicity (Chapter 3.1)

(a) pdf Application of data when the available range data spans more than one acute toxicity range estimate in Table 3.1.2
(Ref. Doc.: ST/SG/AC.10/C.4/2008/23, Annex 2, example 1)
(b) pdf Application of the “relevant ingredients” criteria in paragraph 3.1.3.3
(Ref. Doc.: ST/SG/AC.10/C.4/2008/23, Annex 2, example 2)
(c) pdf Application of the criteria in paragraph 3.1.3.6.1 (c)
(Ref. Doc.: ST/SG/AC.10/C.4/2008/23, Annex 2, example 3)
(d) pdf Application of the criteria in paragraph 3.1.3.2
(Ref. Doc.: ST/SG/AC.10/C.4/2008/23, Annex 2, example 4)
(e) pdf Dilution bridging principle example using acute toxicity data
(Ref. Doc.: ST/SG/AC.10/C.4/2010/15, Annex 2, example 1)
(f) pdf Concentration of highly toxic mixtures bridging principle example using acute toxicity data
(Ref. Doc.: ST/SG/AC.10/C.4/2010/15, Annex 2, example 3)

Skin corrosion/irritation (Chapter 3.2)

(a) pdf Interpolation within one hazard category bridging principle example using skin corrosion/irritation data
(Ref. Doc.: ST/SG/AC.10/C.4/2010/15, Annex 2, example 4)
(b) pdf Interpolation within one hazard category using skin corrosion in vitro data from a Human Skin Model (HSM) test (OECD TG 431)
(Ref. Doc.: ST/SG/AC.10/C.4/2012/25, Annex 2 as amended by INF.35 (24th session)) (Last update: 3 July 2013)
(c) pdf Aerosols bridging principle example using skin corrosion/irritation data
(Ref. Doc.: ST/SG/AC.10/C.4/2010/15, Annex 2, example 6)

Serious eye damage/eye irritation (Chapter 3.3)

(a) pdf application of the relevant ingredients concept for mixtures for serious eye damage/eye irritation
(Ref. Doc.: ST/SG/AC.10/C.4/2008/23, Annex 2, example 6)

Skin corrosion/irritation (Chapter 3.2) and serious eye damage/eye irritation (Chapter 3.3)

(a) pdf Application of data for mixtures when additivity may not apply (paragraphs 3.2.3.3.4 and 3.3.3.3.4)
(Ref. Doc.: ST/SG/AC.10/C.4/2008/23, Annex 2, example 5)
(b) pdf

Classification of a mixture for skin corrosion/irritation and serious eye damage/irritation following the tiered evaluation approach using serious eye damage/eye irritation in vitro data from a Bovine Corneal Opacity and Permeability (BCOP) test (OECD TG 437)
(Ref. Doc.: ST/SG/AC.10/C.4/2012/25, Annex 3)

Respiratory or skin sensitization (Chapter 3.4)

(a) pdf Substancially similar mixtures bridging principle example using skin sensitization data
(Ref. Doc.: ST/SG/AC.10/C.4/2010/15 as amended by INF.40 (20th session), Annex 2)

Specific target organ - single exposure (Chapter 3.8)

(a) pdf Application of the guidance in paragraph 3.8.3.4.5, that is, whether or not additivity should be considered for Specific Target Organ Toxicity – Single Exposure (STOT-SE) Category 3 transient effects
(Ref. Doc.: ST/SG/AC.10/C.4/2008/23, Annex 2, example 7)
(b) pdf Batching bridging principle example using specific target organ toxicity – single dose data
(Ref. Doc.: ST/SG/AC.10/C.4/2010/15, as amended by INF.40 (20th session) Annex 2)

Hazardous to the aquatic environment (Chapter 4.1)

(a) pdf application of the summation methods when classification information is available for some or all of the ingredients of a mixture
(Ref. Doc.: ST/SG/AC.10/C.4/2012/25, Annex 4, example 1)
(b) pdf application of a stepped approach where the additivity formula is used for the part of the mixture that has chronic toxicity data and passing that result into the summation method
(Ref. Doc.: ST/SG/AC.10/C.4/2012/25, Annex 4, example 2)
(c) pdf application of the tiered approach to determining the mixture’s classification where acute toxicity data is available on the mixture as a whole as well as on the ingredients, and chronic classification information is only available on the ingredients
(Ref. Doc.: ST/SG/AC.10/C.4/2012/25, Annex 4, example 3)
(d) pdf classification when there are acute toxicity data as well as hazard classification information available for all relevant components of an untested mixture
(Ref.Doc.: ST/SG/AC.10/C.4/2012/25, Annex 4, example 4)

Section 2: Sector-specific guidance

Note: Links to third party web sites are provided as additional information on GHS. The third parties in question have informed the United Nations Sub-Committee of Experts on the Globally Harmonized System of Classification and Labelling of Chemicals that they had developed guidance on the GHS for their own sectors. However, this does not imply any endorsement of third party’s guidance by the Sub-Committee or the United Nations. The third party remains responsible for the contents of its guidance. Refer also to the “Terms and conditions of use" of the United Nations websites.

Users are reminded that competent authorities will decide how to apply the various elements of the GHS based on their needs and the target audiences. 

Guidance on the application of GHS criteria to petroleum substances
(developed by the International Petroleum Industry Environmental Conservation Association (IPIECA))

Guidance on the application of GHS criteria to ores and concentrates for marine transport
(developed by the International Council of Mining and Metals (ICMM))