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GHS guidance

Guidance on the application of GHS criteria

Note: This webpage contains links to third party web sites which are provided as additional information on GHS. The third parties in question have informed the United Nations Sub-Committee of Experts on the Globally Harmonized System of Classification and Labelling of Chemicals that they had developed guidance on the GHS for their own sectors. However, this does not imply any endorsement of third party’s guidance by the Sub-Committee or the United Nations. The third party remains responsible for the contents of its guidance. Users of this webpage are reminded that competent authorities will decide how to apply the various elements of the GHS based on the needs of the competent authorities and the target audiences. Refer also to the “Terms and conditions of use" of the United Nations websites.

 

Section 1: Examples on the application of GHS criteria
(click on the chapter to expand)

Acute toxicity (Chapter 3.1)

(a)

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Application of data when the available range data spans more than one acute toxicity range estimate in Table 3.1.2
(Ref. Doc.: ST/SG/AC.10/C.4/2008/23, Annex 2, example 1)

(b)

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Application of the “relevant ingredients” criteria in paragraph 3.1.3.3
(Ref. Doc.: ST/SG/AC.10/C.4/2008/23, Annex 2, example 2)

(c)

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Application of the criteria in paragraph 3.1.3.6.1 (c)
(Ref. Doc.: ST/SG/AC.10/C.4/2008/23, Annex 2, example 3)

(d)

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Application of the criteria in paragraph 3.1.3.2
(Ref. Doc.: ST/SG/AC.10/C.4/2008/23, Annex 2, example 4)

(e)

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Dilution bridging principle example using acute toxicity data
(Ref. Doc.: ST/SG/AC.10/C.4/2010/15, Annex 2, example 1)

(f)

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Concentration of highly toxic mixtures bridging principle example using acute toxicity data
(Ref. Doc.: ST/SG/AC.10/C.4/2010/15, Annex 2, example 3)

Skin corrosion/irritation (Chapter 3.2)

(a)

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Interpolation within one hazard category bridging principle example using skin corrosion/irritation data
(Ref. Doc.: ST/SG/AC.10/C.4/2010/15, Annex 2, example 4)

(b)

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Interpolation within one hazard category using skin corrosion in vitro data from a Human Skin Model (HSM) test (OECD TG 431)
(Ref. Doc.: ST/SG/AC.10/C.4/2012/25, Annex 2 as amended by INF.35 (24th session)) (Last update: 3 July 2013)

(c)

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Aerosols bridging principle example using skin corrosion/irritation data
(Ref. Doc.: ST/SG/AC.10/C.4/2010/15, Annex 2, example 6)

Serious eye damage/eye irritation (Chapter 3.3)

(a)

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application of the relevant ingredients concept for mixtures for serious eye damage/eye irritation
(Ref. Doc.: ST/SG/AC.10/C.4/2008/23, Annex 2, example 6)

Skin corrosion/irritation (Chapter 3.2) and serious eye damage/eye irritation (Chapter 3.3)

(a)

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Application of data for mixtures when additivity may not apply (paragraphs 3.2.3.3.4 and 3.3.3.3.4)
(Ref. Doc.: ST/SG/AC.10/C.4/2008/23, Annex 2, example 5)

(b)

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Classification of a mixture for skin corrosion/irritation and serious eye damage/irritation following the tiered evaluation approach using serious eye damage/eye irritation in vitro data from a Bovine Corneal Opacity and Permeability (BCOP) test (OECD TG 437)
(Ref. Doc.: ST/SG/AC.10/C.4/2012/25, Annex 3)

Respiratory or skin sensitization (Chapter 3.4)

(a)

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Substancially similar mixtures bridging principle example using skin sensitization data
(Ref. Doc.: ST/SG/AC.10/C.4/2010/15 as amended by INF.40 (20th session), Annex 2)

Specific target organ - single exposure (Chapter 3.8)

(a)

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Application of the guidance in paragraph 3.8.3.4.5, that is, whether or not additivity should be considered for Specific Target Organ Toxicity – Single Exposure (STOT-SE) Category 3 transient effects
(Ref. Doc.: ST/SG/AC.10/C.4/2008/23, Annex 2, example 7)

(b)

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Batching bridging principle example using specific target organ toxicity – single dose data
(Ref. Doc.: ST/SG/AC.10/C.4/2010/15, as amended by INF.40 (20th session) Annex 2)

Hazardous to the aquatic environment (Chapter 4.1)

(a)

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application of the summation methods when classification information is available for some or all of the ingredients of a mixture
(Ref. Doc.: ST/SG/AC.10/C.4/2012/25, Annex 4, example 1)

(b)

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application of a stepped approach where the additivity formula is used for the part of the mixture that has chronic toxicity data and passing that result into the summation method
(Ref. Doc.: ST/SG/AC.10/C.4/2012/25, Annex 4, example 2)

(c)

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application of the tiered approach to determining the mixture’s classification where acute toxicity data is available on the mixture as a whole as well as on the ingredients, and chronic classification information is only available on the ingredients
(Ref. Doc.: ST/SG/AC.10/C.4/2012/25, Annex 4, example 3)

(d)

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classification when there are acute toxicity data as well as hazard classification information available for all relevant components of an untested mixture
(Ref.Doc.: ST/SG/AC.10/C.4/2012/25, Annex 4, example 4)

Section 2: Sector-specific guidance

Guidance on the application of GHS criteria to petroleum substances
(developed by the International Petroleum Industry Environmental Conservation Association (IPIECA))